The series follows the troubled journey of a large shipment of cocaine from Monterrey, Mexico to Gioia Tauro, Italy. The sellers are the narcos brothers Enrique and Jacinto Leyra, who are aided in their criminal activities by Manuel Contreras and his group of corrupt soldiers; the buyer is Don Minu La Piana, a boss of the 'Ndrangheta, whose position is challenged by his grandson Stefano and the Curtiga family; the brokers in charge of the shipment are the Lynwoods, an American family from New Orleans owning a prestigious shipping company. The infighting within the 'Ndrangheta causes the shipment to be rerouted to Africa, and the delay has dramatic consequences for all the interested parties.