Based on the best-selling series of books by James Patterson, the series revolves around the lives of four women in San Francisco - a homicide detective, an assistant district attorney, a medical examiner and a newspaper reporter - who come together to use their expertise and talents in their respective fields to solve murder cases. Though they lead distinctly different lives, they are bound together by a strong bond of friendship which lead the women to realize that pooling their resources during investigations leads to undiscovered clues and answers in both work and their personal lives.