The Wire chronicled the Baltimore drug scene, seen through the eyes of drug dealers and law enforcement. Every part of the drug "food chain" was depicted, from junkies to dealers, and from cops to politicians. It ran for 5 seasons on HBO, airing its series finale on March 9, 2008.
Shows I've heard are great but some how have not got around to watching yet. As I watch them they will be removed from this list until the list itself dies because of how much of a TV King I've become :P