The Littles is about those who are rarely seen by human eyes, the little people with tails and pointed ears living in the walls of houses and the tiny spaces of the world. These nearly human creatures are known as "The Littles" and they live much as we do, in tightly-knit loving families with the same cares, worries, and joys that we share. But being so tiny in so large a world brings many adventures and jeopardies to the Littles, for something as sweet and cuddly as a household cat is a real menace to them. Henry, a young boy who has discovered the existence of the Littles, joins them in many of their adventures as the Littles live in his home, and also as they travel to many far off places of the world meeting other Littles and having even more adventures.