A sci-fi drama about a woman named Echo and other 'Actives' who are controlled by a shadowy group. Each week, they're programmed with specific personalities in order to service the needs of the wealthy, ranging from hostage negotiation to providing comfort to securing the Dollhouse itself. When finished with the jobs, their minds are wiped clean. Yet, for some, memories linger, and for Echo they become a driving force that she shields from her handlers.