Dust to Dust continues the New Orleans storyline from Blood Trails where fans first met George, an ex-junkie who, while trying to expose the vampires, got captured by the authorities and blamed for the trail of bodies. Our new series begins as Detective Nick Maguire learns that his sister Sara, a nurse at the local penitentiary, disappeared during a mysterious prison break in which George escaped. Nick ignores the wishes of his former partner, Gina, and begins to search for Sara himself. While scouring the gritty streets of New Orleans, Nick finds George and learns that there was more to the prison break than anyone thought, and that the wounds inflicted upon Sara may be changing her into a blood-thirsty vampire. Now, in order to save his sister, Nick will have to learn to trust George, and become a believer in the evil that stalks his streets at night.