Sisters is an uplifting story about what happens when a group of people, from all different walks of life, are suddenly united by a genetic and biological revelation. Julia Bechly is living life as usual, caring for her sick father Julius, until a news story reports that Julius had used his own sperm during the time he was a fertility specialist. She asks her father if it's the truth, which he confirms. Although panicked, Julia decides to throw a "family gathering" to meet all her biological siblings. She finds out she has many many brothers, but only two female siblings, troubled children's television star, Roxy Karibas, and belligerent lawyer, Edie Flanagan.