In Extinct, 400 years after the extinction of humankind by evil aliens called the Kariks, a colony of revived humans, the Reborns, attempt to understand and trust a group of mysterious, peaceful and highly advanced aliens known as the Originators who brought them back to life. The Reborns are guided by Drones who are the face and voice of the Originators. They guide and protect the Reborns throughout their fight against the Kariks, and the parasitic Skin Riders who take control of a "host" or person's cognitive abilities, to restore the human race and end the alien threat that drove mankind to extinction.